CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production.
J Immunol
; 174(3): 1479-90, 2005 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-15661907
ABSTRACT
CD45 is dynamically repositioned within lipid rafts and the immune synapse during T cell activation, although the molecular consequences of CD45 repositioning remain unclear. In this study we examine the role of CD45 membrane compartmentalization in regulating murine T cell activation. We find that raft-localized CD45 antagonizes IL-2 production by opposing processive TCR signals, whereas raft-excluded CD45 promotes ERK-dependent polarized synaptic lipid raft clustering and IL-2 production. We propose that these dual CD45 activities ensure that only robust TCR signals proceed, whereas signals meeting threshold requirements are potentiated. Our findings highlight membrane compartmentalization as a key regulator of CD45 function and elucidate a novel signal transduction pathway by which raft-excluded CD45 positively regulates T cell activation.
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Banco de datos:
MEDLINE
Asunto principal:
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
/
Transducción de Señal
/
Interleucina-2
/
Antígenos Comunes de Leucocito
/
Microdominios de Membrana
/
Quinasas MAP Reguladas por Señal Extracelular
Idioma:
En
Año:
2005
Tipo del documento:
Article