Intestinal myofibroblasts and immune tolerance.
Ann N Y Acad Sci
; 1029: 379-81, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15681786
ABSTRACT
Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4(+) T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens.
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Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-D
/
Inmunidad Mucosa
/
Fibroblastos
/
Tolerancia Inmunológica
/
Intestinos
/
Músculo Liso
Límite:
Humans
Idioma:
En
Año:
2004
Tipo del documento:
Article