Comparison of fine-scale recombination rates in humans and chimpanzees.
Science
; 308(5718): 107-11, 2005 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-15705809
ABSTRACT
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.
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Banco de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Genoma Humano
/
Pan troglodytes
/
Genoma
Tipo de estudio:
Health_economic_evaluation
Límite:
Animals
/
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article