Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain.
Am J Psychiatry
; 162(3): 613-5, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15741483
ABSTRACT
OBJECTIVE:
Association has been reported between the C allele of a -759C/T polymorphism in the promoter of the 5-HT2C receptor gene (HTR2C) and antipsychotic-induced weight gain, suggesting that polymorphic HTR2C expression influences this phenotype. The authors tested this polymorphism, and other promoter variants, for effects on HTR2C transcription.METHOD:
Six HTR2C promoter haplotypes constructed from four polymorphisms were cloned into a luciferase reporter gene plasmid. Their transcriptional activities were then compared in two human cell lines.RESULTS:
All haplotypes containing the -759C allele showed less transcriptional activity than haplotypes containing the -759T allele. The A allele of a -997G/A polymorphism was also associated with reduced expression.CONCLUSIONS:
These findings suggest that the -759C allele is functional and results in relative underexpression of HTR2C. Reduced expression of HTR2C mRNA may underlie vulnerability to weight gain following antipsychotic treatment.
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Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Antipsicóticos
/
Clozapina
/
Receptor de Serotonina 5-HT2C
/
Obesidad
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article