Differential hydrolysis of 1-alkyl-2-acyl and diacylglycerophosphocholines by human and non-human phospholipases A2.
Biochim Biophys Acta
; 1124(3): 297-9, 1992 Mar 25.
Article
en En
| MEDLINE
| ID: mdl-1576169
ABSTRACT
The activity of two human phospholipases A2, purified from synovial fluid and lumbar disc herniations, was tested using alkylacyl- and diacylglycerophosphocholines and the influence of the chemical link at the sn-1 position of glycerol was investigated. Both enzymes exhibited 2.5-3-fold selectivity for 1-ester-linked compared to 1-ether-linked phosphatidylcholine. No significant selectivity was observed with pancreatic phospholipase A2 while Naja naja naja venom enzyme was more efficient against 1-ether-phospholipids.
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Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Fosfolipasas A
/
Factor de Activación Plaquetaria
/
Venenos Elapídicos
Límite:
Humans
Idioma:
En
Año:
1992
Tipo del documento:
Article