The detection of oxycodone in meconium specimens.
J Anal Toxicol
; 29(1): 54-7, 2005.
Article
en En
| MEDLINE
| ID: mdl-15808014
ABSTRACT
A procedure for the determination of oxycodone in meconium using direct ELISA microplate technology followed by electron impact gas chromatography-mass spectrometry (GC-MS) is described for the first time. The abuse of oxycodone (OxyContin) has been widely discussed in mainstream media, and it has been described as a cheap form of heroin. Oxycodone has been reported as having a high degree of abuse and potential complications in neonates from maternal drug use. Using a standard enzyme multiplied immunoassay screening technology, the cross-reactivity of oxycodone to the morphine antibody is only 5-6%. A positive screening value would require a high concentration of drug to be present, so a protocol for the detection of oxycodone in meconium using a direct ELISA microplate immunoassay followed by GC-MS was developed. The assay is now routinely used in our laboratory.
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Banco de datos:
MEDLINE
Asunto principal:
Oxicodona
/
Ensayo de Inmunoadsorción Enzimática
/
Medicina Legal
/
Cromatografía de Gases y Espectrometría de Masas
/
Meconio
/
Narcóticos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Newborn
Idioma:
En
Año:
2005
Tipo del documento:
Article