3,3-Bisaryloxindoles as mineralocorticoid receptor antagonists.

Neel, David A; Brown, Matthew L; Lander, Peter A; Grese, Timothy A; Defauw, Jean M; Doti, Robert A; Fields, Todd; Kelley, Sally Ann; Smith, Stephon; Zimmerman, Karen M; Steinberg, Mitchell I; Jadhav, Prabhakar K

Neel, David A; Brown, Matthew L; Lander, Peter A; Grese, Timothy A; Defauw, Jean M; Doti, Robert A; Fields, Todd; Kelley, Sally Ann; Smith, Stephon; Zimmerman, Karen M; Steinberg, Mitchell I; Jadhav, Prabhakar K.

Neel DA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. neel_david_a@lilly.com

Bioorg Med Chem Lett ; 15(10): 2553-7, 2005 May 16.

Article en En | MEDLINE | ID: mdl-15863315

RESUMEN

Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.

Asunto(s)

Indoles/farmacología; Antagonistas de Receptores de Mineralocorticoides; Humanos; Ensayo de Unión Radioligante

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Banco de datos: MEDLINE Asunto principal: Antagonistas de Receptores de Mineralocorticoides / Indoles Límite: Humans Idioma: En Año: 2005 Tipo del documento: Article

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Imprimir

XML

PubMed Links

Banco de datos: MEDLINE Asunto principal: Antagonistas de Receptores de Mineralocorticoides / Indoles Límite: Humans Idioma: En Año: 2005 Tipo del documento: Article