Two cases of acute myeloid leukemia with t(11;17) associated with varying morphology and immunophenotype: rearrangement of the MLL gene and a region proximal to the RARalpha gene.
Cancer Genet Cytogenet
; 159(2): 168-73, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15899392
ABSTRACT
This report describes 2 cases of acute myeloid leukemia (AML), which based on the WHO classification would be classified as AML with an 11q23 (MLL) abnormality, but with contrasting morphologic and immunophenotypic profiles. One case had monocytic features (morphologically and immunophenotypically) with a t(11;17)(q23;q21), a previously identified variant translocation in acute promyelocytic leukemia (APL). The second case had morphologic and immunophenotypic features of APL associated with a t(11;17)(q23;q25). In both cases, fluorescence-in-situ hybridization (FISH) analysis demonstrated that the 11q23 breakpoint involved the MLL gene, but RARalpha was not involved in the 17q breakpoints. These cases illustrate the importance of FISH analysis to confirm the presence of a particular recurring rearrangement.
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Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Translocación Genética
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Cromosomas Humanos Par 11
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Cromosomas Humanos Par 17
/
Proto-Oncogenes
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Leucemia Mieloide
/
Receptores de Ácido Retinoico
/
Proteínas de Unión al ADN
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2005
Tipo del documento:
Article