Cellular distribution of growth hormone-releasing hormone receptor in human reproductive system and breast and prostate cancers.
Histol Histopathol
; 20(3): 697-706, 2005 07.
Article
en En
| MEDLINE
| ID: mdl-15944917
ABSTRACT
Growth hormone releasing hormone receptor (GHRH-R) mRNA and protein was first localized to the anterior pituitary gland, consequent with the action of its ligand on GH synthesis and release. Subsequent studies found GHRH-R also expressed in the hypothalamus and in systemic tissues including those of the reproductive system. In the present work, we studied the distribution of GHRH-R in human reproductive system of males and females by immunohistochemical method. GHRH-R immunostaining was localized in male reproductive system Leydig cells, Sertoli and basal germ cells of the seminiferous tubules and prostate secretory cells. GHRH-R immunostaining was also demonstrated in the ovary oocytes, follicular cells, granulosa, thecal and corpus luteum cells. Endometrial glands, placenta and normal mammary glands also showed GHRH-R immunostaining. Our results demonstrate the localization of GHRH-R in the reproductive system, which may mediate the direct action of GHRH in these tissues. Moreover, GHRH-R was demonstrated in prostate and breast carcinomas, opening a variety of possibilities for the use of GHRH antagonists in the treatment of prostatic and mammary tumors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ovario
/
Neoplasias de la Próstata
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Testículo
/
Neoplasias de la Mama
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Receptores de Hormona Reguladora de Hormona Hipofisaria
/
Receptores de Neuropéptido
Límite:
Female
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Humans
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Male
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Pregnancy
Idioma:
En
Año:
2005
Tipo del documento:
Article