When is bioavailable testosterone a redundant test in the diagnosis of hypogonadism in men?
Clin Biochem
; 38(9): 813-8, 2005 Sep.
Article
en En
| MEDLINE
| ID: mdl-15961071
ABSTRACT
OBJECTIVES:
Total testosterone (TT) is frequently prescribed with an SHBG and/or free or bioavailable testosterone measurement. Our objective was to identify a TT range for which subsequent SHBG measurement/calculation adds no additional clinical information. DESIGN ANDMETHODS:
Study data were composed of 3955 sets of TT, SHBG and calculated bioavailable testosterone (cBAT) results from unscreened ambulatory male subjects, aged 18-99.RESULTS:
90% of mismatches between TT and cBAT were observed with TT levels between 6.5 and 13.0 nmol/L, with only slight age variation and no important change with albumin level. SHBG measurement restricted to male patients with TT between 6.5 and 13.0 nmol/L should enable reagent cost savings of over 55%.CONCLUSION:
We suggest that a TT level below 6.5 nmol/L or above 13.0 nmol/L provides sufficient useful information for ruling out hypogonadism in ambulatory adult males. This strategy of BAT testing should lead to significant time and cost savings.
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Banco de datos:
MEDLINE
Asunto principal:
Testosterona
/
Pruebas Diagnósticas de Rutina
/
Hipogonadismo
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2005
Tipo del documento:
Article