Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands.
J Med Chem
; 48(15): 4765-71, 2005 Jul 28.
Article
en En
| MEDLINE
| ID: mdl-16033256
ABSTRACT
Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with mu opioid receptor affinity (13) that is an agonist at mu opioid receptors. This represents the identification of a novel structural class of mu opioid receptor agonists.
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Banco de datos:
MEDLINE
Asunto principal:
Pironas
/
Receptores Opioides mu
/
Diterpenos
/
Furanos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article