Novel and expanded jadomycins incorporating non-proteogenic amino acids.
Bioorg Med Chem Lett
; 15(23): 5280-3, 2005 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-16185863
ABSTRACT
Jadomycin B is a secondary metabolite produced, in response to stress, by Streptomyces venezuelae ISP5230 grown in nutrient-deprived media. We present definitive electrospray ionization mass spectrometry data identifying a series of novel jadomycins with non-proteogenic amino acids incorporated into the oxazolone ring of the secondary metabolite, and strengthening evidence for the existence of an aldimine intermediate in the biosynthetic pathway. We also demonstrate that the size of the oxazolone ring can be expanded by incorporating beta-amino acids.
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Banco de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Aminoácidos
/
Isoquinolinas
Idioma:
En
Año:
2005
Tipo del documento:
Article