Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

Freundlich, Joel S; Anderson, John W; Sarantakis, Dimitri; Shieh, Hong-Ming; Yu, Min; Valderramos, Juan-Carlos; Lucumi, Edinson; Kuo, Mack; Jacobs, William R; Fidock, David A; Schiehser, Guy A; Jacobus, David P; Sacchettini, James C

Freundlich, Joel S; Anderson, John W; Sarantakis, Dimitri; Shieh, Hong-Ming; Yu, Min; Valderramos, Juan-Carlos; Lucumi, Edinson; Kuo, Mack; Jacobs, William R; Fidock, David A; Schiehser, Guy A; Jacobus, David P; Sacchettini, James C.

Freundlich JS; Department of Medicinal Chemistry, Jacobus Pharmaceutical Company, 37 Cleveland Lane, Princeton, NJ 08540, USA. j_freundlich@jacobuspharm.com

Bioorg Med Chem Lett ; 15(23): 5247-52, 2005 Dec 01.

Article en En | MEDLINE | ID: mdl-16198563

Asunto(s)

Antimaláricos/química; Antimaláricos/farmacología; Enoil-ACP Reductasa (NADH)/antagonistas & inhibidores; Plasmodium falciparum/enzimología; Triclosán/análogos & derivados; Animales; Antimaláricos/síntesis química; Cristalografía por Rayos X; Estructura Molecular; Plasmodium falciparum/efectos de los fármacos; Triclosán/química

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Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Triclosán / Enoil-ACP Reductasa (NADH) / Antimaláricos Límite: Animals Idioma: En Año: 2005 Tipo del documento: Article

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