Transcriptional repression by a novel member of the bZIP family of transcription factors.
Mol Cell Biol
; 12(7): 3070-7, 1992 Jul.
Article
en En
| MEDLINE
| ID: mdl-1620116
ABSTRACT
We describe here a novel member of the bZIP family of DNA-binding proteins, designated E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the activating transcription factor family of factors. When expressed in a transient transfection assay with a suitable reporter plasmid, E4BP4 strongly repressed transcription in a DNA-binding-site-dependent manner. Examination of a series of deletion mutants revealed that sequences responsible for the repressing potential of E4BP4 lie within the carboxyl-terminal region of the protein. No similarity was found between this region and the repressing domains of other known eukaryotic transcriptional repressors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Plantas
/
Proteínas Represoras
/
Factores de Transcripción
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Año:
1992
Tipo del documento:
Article