Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Bioorg Med Chem Lett
; 16(1): 118-22, 2006 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-16216497
ABSTRACT
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
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Banco de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Pirimidinas
/
Familia-src Quinasas
/
Proteína Tirosina Quinasa p56(lck) Específica de Linfocito
/
Rechazo de Injerto
/
Inmunosupresores
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article