On the TRAIL of a new therapy for leukemia.
Leukemia
; 19(12): 2195-202, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16224489
ABSTRACT
The cytokine TRAIL (tumor necrosis factor alpha-related apoptosis-inducing ligand) as well as agonistic antibodies that bind to the TRAIL receptors, death receptor 4 (DR4) and DR5, are undergoing preclinical and early clinical evaluation as potential therapeutic agents for a variety of hematological and nonhematological malignancies. Here, we briefly review the normal biological function of TRAIL, the mechanism of cytotoxicity of TRAIL receptor ligands, and their effects on normal myeloid progenitors, myelodysplastic marrow and leukemic cells, including acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL), in vitro. Recent observations suggesting that DR4 is the predominant receptor for the cytotoxic effects of TRAIL in CLL and that histone deacetylase inhibitors synergize with TRAIL in CLL in vitro are described and discussed. Collectively, the reviewed studies not only illustrate the potential therapeutic usefulness of TRAIL and the agonistic antibodies, but also highlight the need for additional preclinical evaluation of these agents.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Leucemia
/
Factor de Necrosis Tumoral alfa
/
Proteínas Reguladoras de la Apoptosis
Límite:
Humans
Idioma:
En
Año:
2005
Tipo del documento:
Article