[The expression of Maspin and VEGF gene in oral squamous cell carcinoma and its significance].

ABSTRACT

PURPOSE: To study the expression of Maspin(marray serine proteinase inhibitor) and VEGF(vascular endothelial growth factor) gene in oral squamous cell cancers(OSCC) and the relationship between Maspin and VEGF. METHODS: mRNA expression of Maspin and VEGF gene was investigated by RT-PCR in every samples of 18 OSCC cases. F test and Person test were used for data analysis. RESULTS: mRNA expression of Maspin gene increased gradually in OSCC, paratumor and normal epithelium(P<0.01); mRNA expression of VEGF gene decreased gradually in OSCC,paratumor and normal epithelium(P<0.01); The expression of Maspin and VEGF gene was negatively correlated in OSCC(P<0.01) ; The expression of Maspin gene was negatively associated but VEGF gene was positively associated with lymph node metastasis in OSCC(P<0.05); The expression of Maspin and VEGF gene had no relation with the histological grade or tumor size in OSCC. CONCLUSION: Maspin and VEGF gene may play an important role in the development of OSCC and Maspin gene may down-regulate the expression of VEGF gene.