TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients.
Microbes Infect
; 8(3): 598-603, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16427798
ABSTRACT
Chronic Chagas' disease cardiomyopathy (CCC) is the most important clinical outcome of infection by the parasite Trypanosoma cruzi, affecting 18 million individuals in Latin America. One-third of CCC patients develop heart failure due to end-stage dilated cardiomyopathy, and their survival is reduced by 50% compared to patients with other cardiomyopathies. Genetic susceptibility may play a role in the differential survival of severe CCC patients. Given the role of TNF-alpha in the progression of heart failure, and the increased TNF-alpha plasma and heart tissue levels observed in these patients, we chose TNF as a candidate gene for increased mortality in severe CCC patients. We typed the TNFa microsatellite and the -308 TNF promoter polymorphism and then analyzed the survival curves of 42 patients with severe ventricular dysfunction (left ventricular ejection fraction
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Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Cardiomiopatía Chagásica
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Factor de Necrosis Tumoral alfa
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Predisposición Genética a la Enfermedad
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2006
Tipo del documento:
Article