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Antitumor activity of doxorubicin encapsulated in hexadecylphosphocholine (HePC) liposomes against human xenografts on Scid mice.
Papagiannaros, A; Hatziantoniou, S; Lelong-Rebel, I H; Papaioannou, G T; Dimas, K; Demetzos, C.
  • Papagiannaros A; Department of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771, Athens, Greece.
In Vivo ; 20(1): 129-35, 2006.
Article en En | MEDLINE | ID: mdl-16433041
ABSTRACT
Doxorubicin was encapsulated into liposomes composed of hexadecylphosphocholineegg yolk phosphatidylcholinestearylamine (HePC.EPCSA) 1010.0.1 (molar ratio) (1) and EPCSA 100.1 (molar ratio) (2). Liposomal formulations 1 and 2, as well as free doxorubicin and free HePC, were tested in vitro against HCT116 human colon cancer cell lines and peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, using the sulphorodamine B assay. The activity of doxorubicin was retained or slightly improved when entrapped into liposomes 1 and 2, while liposomal formulation 1 incorporating doxorubicin was found to be less toxic against normal cells. The liposomes were tested in vivo against human colon cancer xenografts in scid mice. The antitumor activities of liposomes 1 and 2 were statistically similar to that of free doxorubicin, but their toxicity was significantly lower. Based on these results, the combination of HePC and doxorubicin in one liposomal formulation may be justified for further evaluation.
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Fosforilcolina / Doxorrubicina / Neoplasias del Colon / Antineoplásicos Límite: Animals Idioma: En Año: 2006 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Fosforilcolina / Doxorrubicina / Neoplasias del Colon / Antineoplásicos Límite: Animals Idioma: En Año: 2006 Tipo del documento: Article