Antimitotic agents of natural origin.
Curr Drug Targets
; 7(3): 305-26, 2006 Mar.
Article
en En
| MEDLINE
| ID: mdl-16515529
ABSTRACT
Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.
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Banco de datos:
MEDLINE
Asunto principal:
Productos Biológicos
/
Antimitóticos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article