Myeloid sarcoma occurring concurrently with drug-induced gingival enlargement.
J Periodontol
; 77(1): 119-22, 2006 Jan.
Article
en En
| MEDLINE
| ID: mdl-16579712
ABSTRACT
BACKGROUND:
Myeloid sarcoma is an extramedullary malignancy of myeloblasts. An unusual case of myeloid sarcoma presenting in the gingiva and affected by drug-induced gingival enlargement is presented.METHODS:
A 63-year-old male taking amlodipine for his hypertension presented with a 3-week gingival enlargement. Although the obvious clinical impression was that of drug-induced gingival enlargement, an incisional biopsy was performed to corroborate chemical enlargement while ruling out diseases such as lymphoma and leukemia.RESULTS:
Microscopic examination of the thickened gingiva revealed surface stratified squamous epithelium having needle-like rete pegs characteristic of drug-induced gingival enlargement. Beneath the surface epithelium, the fibrous tissue was virtually replaced by a dense infiltrate of malignant cells. Immunohistochemical studies were performed with CD117 and myeloperoxidase identifying the malignant cell population as myeloblasts, leading to a diagnosis of myeloid sarcoma.CONCLUSION:
Myeloid sarcoma and hematopoietic malignancies must be included in a differential diagnosis of gingival enlargement until the definitive diagnosis is reached by histologic/laboratory examination.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gingivales
/
Leucemia Mieloide
/
Amlodipino
/
Sobrecrecimiento Gingival
/
Antihipertensivos
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2006
Tipo del documento:
Article