Cloning and characterization of the gene encoding rabbit cardiac calsequestrin.
Gene
; 109(2): 275-9, 1991 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-1662658
ABSTRACT
A cDNA encoding rabbit cardiac calsequestrin was isolated and characterized. The deduced nascent cardiac calsequestrin contains 409 amino acids of which 26% are acidic residues, and had 93% and 67% aa identity with canine cardiac calsequestrin and rabbit fast-twitch skeletal muscle calsequestrin, respectively. RNA blot analyses indicate that this mRNA is expressed in atrium, ventricle and to a lesser amount in slow-twitch skeletal muscle. This mRNA transcript is not expressed in adult fast-twitch skeletal muscle, smooth muscle, or nonmuscle tissues. Analysis of in vitro skeletal muscle myogenesis using a mouse myoblast cell line C2C12, demonstrates that both cardiac and skeletal calsequestrin isoforms are coproduced during muscle differentiation.
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Banco de datos:
MEDLINE
Asunto principal:
Calsecuestrina
/
Músculos
/
Miocardio
Límite:
Animals
Idioma:
En
Año:
1991
Tipo del documento:
Article