Inhibition of adhesion-promoting activity of a human salivary protein which promotes adhesion of Streptococcus mutans JBP to hydroxyapatite.
FEMS Microbiol Lett
; 69(1): 19-22, 1991 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-1664400
ABSTRACT
The adhesion-promoting proteins (APP) (molecular mass approx. 300 kDa), which promote adhesion of Streptococcus mutans JBP (serotype c) to hydroxyapatite, were isolated from human submandibular-sublingual (SMSL) saliva by gel filtration on a Trisacryl GP2000 M column. The effects of hexoses, pentoses, methyl-pentoses, hexosamines, N-acetylhexosamines, a basic amino acid, polyamines and ammonium chloride on the bacterial adhesion-promoting activity of the APP were examined. Galactosamine, mannosamine, L-lysine, spermine, putrescine, and ammonium chloride inhibited the adhesion-promoting activities of the APP. The other sugars, including the N-acetylhexosamines, were without effect. Thus, compounds containing a primary amino-group appear to have a specific inhibitory effect on adhesion of S. mutans JBP to APP adsorbed onto hydroxyapatite, an activity which is lost if the amino-group is acetylated.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas y Péptidos Salivales
/
Streptococcus mutans
/
Adhesión Bacteriana
/
Hidroxiapatitas
Límite:
Humans
/
Male
Idioma:
En
Año:
1991
Tipo del documento:
Article