Anti-hepatitis delta virus seroprevalence and risk factors in patients with hepatitis B in Southeast Turkey.
Saudi Med J
; 27(5): 617-20, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16680248
ABSTRACT
OBJECTIVE:
To obtain regional epidemiological data on hepatitis delta virus (HDV, a defective virus) infections, the incidence of anti-HDV positivity and the associated risk factors in asymptomatic hepatitis B virus surface antigen (HBsAg) carriers and in patients with chronic active hepatitis B.METHODS:
The study took place at Dicle University Hospital (Diyarbakir, Southeast of Turkey) between January 2002 and July 2004. Anti-HDV screening was performed in asymptomatic hepatitis B carriers (N=889) and in patients with chronic active hepatitis B infection (N=120). We explored the association between anti-HDV positivity and asymptomatic hepatitis B carrier status, presence of active hepatitis B, age, gender, the durations of HBsAg positivity and hepatitis B e antigen (HBeAg) positivity.RESULTS:
In 6% of asymptomatic hepatitis B carriers (53/889) and in 27.5% of patients with chronic active hepatitis B (33/120) anti-HDV was positive. The incidence of anti-HDV positivity was significantly higher in patients with chronic active hepatitis B compared with asymptomatic carriers (p<0.001). A significant association between the duration of HBsAg carrier status (3.2 +/- 1.4 years) and anti-HDV positivity was also found (p<0.001). Age, gender, and HBeAg positivity were not significantly associated with anti-HDV positivity (p>0.05).CONCLUSION:
Anti-HDV positivity was significantly more common in patients with chronic hepatitis B compared with asymptomatic hepatitis B virus (HBV) carriers in a region with a high prevalence of HBV infection. We found a significant relationship between the duration of HBsAg carrier status and anti-HDV positively, however, age, gender, and presence of HBeAg were not significantly associated with the development of anti-HDV positivity.
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Banco de datos:
MEDLINE
Asunto principal:
Hepatitis D
/
Virus de la Hepatitis Delta
/
Antígenos de Hepatitis delta
/
Hepatitis B
/
Antígenos e de la Hepatitis B
/
Antígenos de Superficie de la Hepatitis B
/
Anticuerpos Antivirales
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País como asunto:
Asia
Idioma:
En
Año:
2006
Tipo del documento:
Article