Expression of EGFR and LRIG-1 in human trigeminal neurinoma.
J Huazhong Univ Sci Technolog Med Sci
; 26(1): 86-8, 2006.
Article
en En
| MEDLINE
| ID: mdl-16711015
ABSTRACT
The expression of epidermal growth factor receptor (EGFR) and leucine-rich repeats and immunoglobulin-like domain 1 (LRIG-1) in human trigeminal neurinoma was investigated and their effect on the origination and development of trigeminal neurinoma, and the relationship between them was studied. By using immunohistochemistry with tissue chip, the expression of EGFR and LRIG-1 was detected in 23 cases of trigeminal neurinoma. It was found that in the 23 cases, the expression rate of EGFR was 21.74%, while that of the LRIG-1 was 78.26%. There was a negative correlation between them. It was suggested that LRIG-1 might inhibit the malignant differentiation and proliferation of the trigeminal neurinoma possibly by the negative feedback loop of EGFR.
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Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Neoplasias de los Nervios Craneales
/
Enfermedades del Nervio Trigémino
/
Receptores ErbB
/
Neurilemoma
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2006
Tipo del documento:
Article