No-carrier-added nucleophilic 18F-labelling in an electrochemical cell exemplified by the routine production of [18F]altanserin.
Appl Radiat Isot
; 64(9): 989-94, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16829074
ABSTRACT
A new type of electrochemical cell with anodic deposition of no-carrier-added [(18)F]fluoride and variable reaction volume has been developed. The reactor is designed for small reaction volumes and non-thermal drying of [(18)F]fluoride. The implementation of this reactor into a complete remotely controlled synthesis device is described for the routine production of [(18)F]altanserin. A radiochemical yield of 23+/-5% was obtained via cryptate-mediated nucleophilic (18)F-fluorination. Batches of up to 6 GBq [(18)F]altanserin, suitable for human application, with a molar activity of >500 GBq/micromol were obtained within 75 min.
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Banco de datos:
MEDLINE
Asunto principal:
Ketanserina
/
Radioisótopos de Flúor
/
Marcaje Isotópico
Idioma:
En
Año:
2006
Tipo del documento:
Article