Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.
Bioorg Med Chem Lett
; 16(19): 5022-7, 2006 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-16876411
ABSTRACT
A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Ácidos Borónicos
/
Factor XIa
/
Anticoagulantes
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article