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Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Martin, Matthew W; Newcomb, John; Nunes, Joseph J; McGowan, David C; Armistead, David M; Boucher, Christina; Buchanan, John L; Buckner, William; Chai, Lilly; Elbaum, Daniel; Epstein, Linda F; Faust, Theodore; Flynn, Shaun; Gallant, Paul; Gore, Anu; Gu, Yan; Hsieh, Faye; Huang, Xin; Lee, Josie H; Metz, Daniela; Middleton, Scot; Mohn, Deanna; Morgenstern, Kurt; Morrison, Michael J; Novak, Perry M; Oliveira-dos-Santos, Antonio; Powers, David; Rose, Paul; Schneider, Stephen; Sell, Stephanie; Tudor, Yanyan; Turci, Susan M; Welcher, Andrew A; White, Ryan D; Zack, Debra; Zhao, Huilin; Zhu, Li; Zhu, Xiaotian; Ghiron, Chiara; Amouzegh, Patricia; Ermann, Monika; Jenkins, James; Johnston, David; Napier, Spencer; Power, Eoin.
  • Martin MW; Department of Chemistry Research and Discovery, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA. matmarti@amgen.com
J Med Chem ; 49(16): 4981-91, 2006 Aug 10.
Article en En | MEDLINE | ID: mdl-16884310
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Banco de datos: MEDLINE Asunto principal: Pirimidinas / Carbamatos / Proteína Tirosina Quinasa p56(lck) Específica de Linfocito / Aminopiridinas / Antiinflamatorios Límite: Animals / Humans Idioma: En Año: 2006 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Pirimidinas / Carbamatos / Proteína Tirosina Quinasa p56(lck) Específica de Linfocito / Aminopiridinas / Antiinflamatorios Límite: Animals / Humans Idioma: En Año: 2006 Tipo del documento: Article