Mucosal fibrosis in intestinal transplant biopsies correlates positively with the development of chronic rejection.
Transplant Proc
; 38(6): 1685-6, 2006.
Article
en En
| MEDLINE
| ID: mdl-16908247
ABSTRACT
Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33% of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.
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Banco de datos:
MEDLINE
Asunto principal:
Trasplante Homólogo
/
Rechazo de Injerto
/
Mucosa Intestinal
/
Intestinos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2006
Tipo del documento:
Article