Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation.
Arch Dermatol
; 142(8): 985-90, 2006 Aug.
Article
en En
| MEDLINE
| ID: mdl-16924047
ABSTRACT
OBJECTIVE:
To evaluate efficacy and adverse effects of intense pulsed light rejuvenation in a homogeneous group of patients.DESIGN:
Randomized controlled split-face trial.SETTING:
University dermatology department. PATIENTS Thirty-two female volunteers with Fitzpatrick skin type I through III and class I or II rhytids.INTERVENTIONS:
Subjects were randomized to 3 intense pulsed light treatments at 1-month intervals or to no treatment of right or left sides of the face. MAIN OUTCOMEMEASURES:
Primary end points were skin texture and rhytids. Secondary end points were telangiectasia, irregular pigmentation, and adverse effects. Efficacy was evaluated by patient self-assessments and by blinded clinical and photographic evaluations up to 9 months after final treatment. Adverse effects were assessed clinically and by noninvasive skin reflectance measurements.RESULTS:
Skin texture was significantly improved at all clinical assessments except at the 6-month examination (P<.006). The improvements peaked at 1 month after treatment, at which time 23 (82%) of 28 patients had better appearances of treated vs untreated sides. Most patients obtained mild or moderate improvements, and 16 patients (58%) self-reported mild or moderate efficacy on skin texture. Rhytids were not significantly different on treated vs untreated sides, and 19 patients (68%) reported uncertain or no efficacy on rhytids. Significant improvements of telangiectasia (P<.001) and irregular pigmentation (P<.03) were found at all assessments. Three patients withdrew from the study because of pain related to treatment.CONCLUSIONS:
Three intense pulsed light treatments improved skin texture, telangiectasia, and irregular pigmentation but had no efficacy on rhytids. Adverse events were minimal, but included scar in 1 patient.
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Banco de datos:
MEDLINE
Asunto principal:
Fototerapia
/
Envejecimiento de la Piel
/
Dermatosis Facial
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Año:
2006
Tipo del documento:
Article