Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy.
Proc Natl Acad Sci U S A
; 103(43): 15975-80, 2006 Oct 24.
Article
en En
| MEDLINE
| ID: mdl-17043243
ABSTRACT
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Galectina 1
/
Neoplasias
Tipo de estudio:
Guideline
Límite:
Animals
/
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article