Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine.
Am J Psychiatry
; 163(11): 2005-7, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-17074955
ABSTRACT
OBJECTIVE:
The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications.METHOD:
Magnetic resonance imaging scans were acquired from 10 subjects with chronic schizophrenia taking typical antipsychotics and 20 healthy volunteers. Subjects with schizophrenia were switched to olanzapine; both groups were rescanned.RESULTS:
At baseline, thalamic volumes in subjects with chronic schizophrenia were 5.8% greater than those of healthy volunteers. At follow-up, there was no significant difference between groups. Additional analysis revealed a significant positive correlation between baseline thalamic volume and dosage of typical antipsychotic medication. Higher dosages at baseline were correlated with larger reductions in volume after the switch to olanzapine.CONCLUSIONS:
Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers.
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Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Tálamo
/
Antipsicóticos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2006
Tipo del documento:
Article