Maternal antiretroviral drugs during pregnancy and infant low birth weight and preterm birth.
AIDS
; 20(18): 2345-53, 2006 Nov 28.
Article
en En
| MEDLINE
| ID: mdl-17117021
ABSTRACT
OBJECTIVE:
To determine the relationship between maternal antiretroviral regimens during pregnancy and adverse infant outcomes [low birth weight (LBW) and preterm birth]. The a priori hypothesis was that protease inhibitor (PI)-containing regimens are associated with an increased risk of LBW and preterm birth.DESIGN:
Prospective cohort study of HIV-1-infected women and their infants (NISDI Perinatal Study).METHODS:
Data were analysed from 681 women receiving at least one antiretroviral drug [in order of increasing complexity one or two nucleoside reverse transcriptase inhibitors (1-2 NRTI), two NRTI plus one non-nucleoside reverse transcriptase inhibitor (NNRTI) (HAART/NNRTI), or two NRTI plus one PI (HAART/PI)] for at least 28 days during pregnancy, and who delivered live born, singleton infants with known birth weight and gestational age by 1 March 2005. Multivariable logistic regression modeling was used to assess the relationship of maternal ART with LBW and with preterm birth, adjusting for covariates.RESULTS:
The incidence of LBW and preterm birth, respectively, was 9.6% and 7.4% (1-2 NRTI), 7.4% and 5.8% (HAART/NNRTI), and 16.7% and 10.6% (HAART/PI). There was no statistically significant increased risk of LBW [adjusted odds ratio (AOR), 1.5; 95% confidence interval (95% CI), 0.7-3.2] or preterm birth (AOR, 1.1; 95% CI, 0.5-2.8) among women who received HAART/PI compared with women receiving 1-2 NRTI.CONCLUSIONS:
Among a population of HIV-1-infected women in Latin America and the Caribbean, maternal receipt of PI-containing ART regimens during pregnancy was not associated with a statistically significant increase in risk of LBW or preterm birth.
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Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Recién Nacido de Bajo Peso
/
Recien Nacido Prematuro
/
Infecciones por VIH
/
VIH-1
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
País como asunto:
America do sul
/
Argentina
/
Bahamas
/
Brasil
/
Caribe ingles
/
Mexico
Idioma:
En
Año:
2006
Tipo del documento:
Article