Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.
Cardiovasc Drugs Ther
; 20(5): 327-34, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-17119877
ABSTRACT
PURPOSE:
We assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine.METHODS:
All swine were subjected to 12-min ischemia followed by reperfusion to produce myocardial stunning. Group A (n = 12) received saline in place of milrinone both before and after ischemia. Group B (n = 9) and C (n = 9) received intravenous milrinone at a rate of 5 microg/kg/min for 10 min followed by 0.5 microg/kg/min for 10 min and 10 microg/kg/min for 10 min followed by 1 microg/kg/min for 10 min, respectively, until 30 min before coronary occlusion. Group D (n = 7) received the same dose of milrinone as group B starting 1 min after reperfusion. Myocardial contractility was assessed by percentage segment shortening (%SS).RESULTS:
Five swine in group A and two swine in groups B and C each had ventricular fibrillation or tachycardia after reperfusion, and were thus excluded from further analysis. The percentage changes of %SS from the baseline 90 min after reperfusion in groups B, C, and D were 78 +/- 9%, 82 +/- 13%, and 79 +/- 7%, respectively, which were significantly higher than those in group A (43 +/- 13%).CONCLUSION:
We conclude that milrinone administered before ischemia or just after reperfusion attenuates myocardial stunning.
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Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Fosfodiesterasa
/
Cardiotónicos
/
Aturdimiento Miocárdico
/
Milrinona
Límite:
Animals
Idioma:
En
Año:
2006
Tipo del documento:
Article