Determination of propoxyphene in oral fluid.
J Anal Toxicol
; 30(8): 516-8, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-17132245
ABSTRACT
The determination of propoxyphene in oral fluid using solid-phase extraction and gas chromatography-mass spectrometry is described for the first time. The method employs collection of oral fluid with the Quantisal device, immunoassay screening of the specimen, confirmation of the positive screened samples after extraction using cation exchange/hydrophobic solid-phase extraction columns, optimized derivative formation, and gas chromatography-mass spectrometry in electron impact mode. Validated parameters including selectivity, linearity, accuracy, intra- and interday precision, extraction efficiency, and limit of quantitation were all within acceptable limits. The method was applied to authentic specimens taken from an individual prescribed propoxyphene following surgery.
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Banco de datos:
MEDLINE
Asunto principal:
Dextropropoxifeno
/
Saliva
/
Cromatografía de Gases y Espectrometría de Masas
/
Narcóticos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article