[Immunochemical study of antigenic determinants of surface protein s of the tropical malaria pathogen Plasmodium falciparum using synthetic peptides]. / Immunokhimicheskoe izuchenie antigennykh determinant poverkhnostnykh belkov vozbuditelia tropicheskoi maliarii Plasmodium falciparum s pomoshch'iu sinteticheskikh peptidov.

ABSTRACT

To develop new approaches to diagnostics and therapy of malaria, we carried out immunochemical study of the surface proteins of the tropical malaria parasite Plasmodium falciparum with the use of synthetic peptides corresponding to the suggested antigenic determinants of the parasite proteins. Rabbit antisera raised against the synthetic peptides bound to parasite proteins as shown by ELISA and immunoblotting. Affinity purified anti-peptide antibodies inhibited, in some cases, the parasite growth in the human erythrocytes culture.