Early oxidative stress in amniotic fluid of pregnancies with Down syndrome.
Clin Biochem
; 40(3-4): 177-80, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17208212
ABSTRACT
OBJECTIVE:
Some evidence suggests that oxidative stress, due to an imbalance between oxidants and antioxidants, occurs in babies with Down syndrome (DS). This study tests the hypothesis that oxidative stress occurs early in DS pregnancies. DESIGN ANDMETHODS:
Isoprostanes (IPs), a new marker of free radical-catalyzed lipid peroxidation, were measured in amniotic fluid from pregnancies with normal, growth restricted and DS fetuses, diagnosed by karyotype analysis of amniotic cells cultured.RESULTS:
A nine-fold increase in IP concentrations was found in amniotic fluid of pregnancies with DS fetuses. This increase (595.15; 542.96-631.64 pg/ml, median; 95% CI), was greater than in pregnancies with fetal growth-restricted fetuses (155; 130.57-172.23 pg/ml, median; 95% CI) and normal fetuses (67; 49.82-98.38 pg/ml, median; 95% CI; p<0.0001).CONCLUSIONS:
The study reveals that oxidative stress occurs early in pregnancy and supports the idea of testing whether prenatal antioxidant therapy may prevent or delay the onset of oxidative stress diseases in the DS population.
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Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Prenatal
/
Síndrome de Down
/
Estrés Oxidativo
/
Isoprostanos
/
Líquido Amniótico
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
2007
Tipo del documento:
Article