Maspin nuclear localization is related to reduced density of tumour-associated micro-vessels in laryngeal carcinoma.
Anticancer Res
; 26(6C): 4927-32, 2006.
Article
en En
| MEDLINE
| ID: mdl-17214364
ABSTRACT
BACKGROUND:
MASPIN, a tumour suppressing serpin, is a potent inhibitor of angiogenesis. CD105 is a proliferation-associated protein acting in endothelial cells of angiogenic tissues. For the first time the relation between nuclear MASPIN expression and CD105-assessed micro-vessel density (MVD) in laryngeal carcinoma was investigated. PATIENTS ANDMETHODS:
The sub-cellular distribution of MASPIN and nuclear MASPIN expression were immunohistochemically determined in 35 cases of laryngeal carcinoma. The percentage of the fields occupied by CDl05-assessed micro-vessels was also calculated.RESULTS:
MVD was significantly lower in laryngeal carcinomas with MASPIN nuclear staining than in carcinomas with cytoplasmic staining (p=0.02). The mean nuclear MASPIN expression was higher in patients without carcinoma recurrence than in those with recurrence (p=0.06). The mean MVD was significantly higher in patients with recurrence of carcinoma (p=0.024).CONCLUSION:
The crucial role of MASPIN nuclear localization in reducing the MVD has been demonstrated. Nuclear MASPIN re-expression should be investigated as a potential therapeutic option in the treatment of laryngeal carcinoma.
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Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Serpinas
/
Neoplasias Laríngeas
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2006
Tipo del documento:
Article