Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
J Pediatr
; 150(2): 140-5, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17236890
ABSTRACT
OBJECTIVES:
To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism. STUDYDESIGN:
Twenty-four infants with hyperinsulinism unresponsive to medical therapy were studied. Patients were injected intravenously with [18F]-DOPA, and PET scans were obtained for 1 hour. Images were coregistered with abdominal CT scans.RESULTS:
The diagnosis of focal or diffuse hyperinsulinism was correct in 23 of the 24 cases (96%) and equivocal in 1 case. [18F]-DOPA PET identified focal areas of high uptake of radiopharmaceutical in 11 patients. Pathology results confirmed that all 11 had focal adenomatosis, and the locations of these lesions matched the areas of increased [18F]-DOPA uptake on the PET scans in all of the cases.CONCLUSIONS:
[18F]-DOPA PET scans were 96% accurate in diagnosing focal or diffuse disease and 100% accurate in localizing the focal lesion. These results suggest that [18F]-DOPA PET imaging should be considered in all infants with congenital hyperinsulinism who need to have pancreatectomy.
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Banco de datos:
MEDLINE
Asunto principal:
Dihidroxifenilalanina
/
Hiperinsulinismo Congénito
/
Tomografía de Emisión de Positrones
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Infant
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Male
/
Newborn
Idioma:
En
Año:
2007
Tipo del documento:
Article