Microvesicle-associated tissue factor and Trousseau's syndrome.
J Thromb Haemost
; 5(1): 70-4, 2007 Jan.
Article
en En
| MEDLINE
| ID: mdl-17239164
ABSTRACT
BACKGROUND:
Trousseau's syndrome is a prothrombotic state associated with malignancy that is poorly understood pathophysiologically. METHODS ANDRESULTS:
Here we report studies on the blood of a 55-year-old man with giant-cell lung carcinoma who developed a severe form of Trousseau's syndrome. His clinical course was dominated by an extremely hypercoagulable state. Despite receiving potent antithrombotic therapy, he suffered eleven major arterial and venous thrombotic events over a 5 month period. We examined the patient's blood for tissue factor (TF), the major initiator of coagulation, and found its concentration in his plasma to be forty-one-fold higher than the mean concentration derived from testing of 16 normal individuals.CONCLUSION:
Almost all of the TF in the patient's plasma was associated with cell-derived microvesicles, likely shed by the cancer cells.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trombosis
/
Tromboplastina
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Carcinoma de Células Gigantes
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Vesículas Citoplasmáticas
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Neoplasias Pulmonares
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2007
Tipo del documento:
Article