Motor impairment and neuronal damage following hypothermia in tropical amphibians.
Int J Exp Pathol
; 88(1): 1-7, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17244333
ABSTRACT
Although the induction of mild to moderate cerebral hypothermia in mammals can have neuroprotective activity, some deleterious effects have been described when inducing deep hypothermia during cooling of the brain. In the spinal cord, rapid deep cooling can induce seizure activity accompanied by release of the excitatory neurotransmitters, glutamate and aspartate. We used cold-sensitive tropical amphibians as a model to determine (a) the critical temperature inside the central nervous system necessary to induce seizures during rapid cooling; (b) the survival rate during slow deep cooling of the whole animal; and (c) whether deep cooling can cause neuronal cell damage. Seizures induced by deep rapid (
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Médula Espinal
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Encéfalo
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Anfibios
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Hipotermia Inducida
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article