HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.
AIDS
; 21(5): 645-7, 2007 Mar 12.
Article
en En
| MEDLINE
| ID: mdl-17314528
ABSTRACT
Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.
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Banco de datos:
MEDLINE
Asunto principal:
Replicación Viral
/
Infecciones por VIH
/
Proteínas del Envoltorio Viral
/
VIH-1
Límite:
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article