Importance of allogeneic T-cells for disease control after stem cell transplantation for high-risk Langerhans cell histiocytosis.
Haematologica
; 92(1): e3-4, 2007 Jan.
Article
en En
| MEDLINE
| ID: mdl-17405740
ABSTRACT
Reduced intensity conditioning followed by allogeneic SCT (RIC-SCT) has recently emerged as promising new salvage option for children suffering from Langerhans cell histiocytosis (LCH) with risk organ involvement and failure to conventional therapy. We report on the posttransplant course of female toddler with high-risk LCH, who achieved complete remission after RIC-SCT, despite a posttransplant chimerism constellation, in which only the T-cell subset proved to be of donor origin in the long-term. We therefore suggest that allogeneic T-cells have played a crucial role in controlling disease activity in this patient and may exert the major curative effect after RIC-SCT for LCH.
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Banco de datos:
MEDLINE
Asunto principal:
Histiocitosis de Células de Langerhans
/
Subgrupos de Linfocitos T
/
Trasplante de Médula Ósea
/
Acondicionamiento Pretrasplante
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Año:
2007
Tipo del documento:
Article