A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression.
Cancer Res
; 67(7): 3337-44, 2007 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-17409443
ABSTRACT
Overexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY) attached to the proapoptotic alpha-tocopheryl succinate (alpha-TOS). Treating erbB2-low or erbB2-high cells with alpha-TOS induced similar levels of apoptosis, whereas alpha-TOS-LTVSPWY induced greater levels of apoptosis in erbB2-high cells. alpha-TOS rapidly accumulated in erbB2-high cells exposed to alpha-TOS-LTVSPWY. The extent of apoptosis induced in erbB2-high cells by alpha-TOS-LTVSPWY was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. alpha-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice. We conclude that a conjugate of a peptide targeting alpha-TOS to erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors.
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Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Vitamina E
/
Neoplasias de la Mama
/
Receptor ErbB-2
Límite:
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article