Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.

Ren, Jingshan; Nichols, Charles E; Chamberlain, Philip P; Weaver, Kurt L; Short, Steven A; Chan, Joseph H; Kleim, Jörg-Peter; Stammers, David K

Ren, Jingshan; Nichols, Charles E; Chamberlain, Philip P; Weaver, Kurt L; Short, Steven A; Chan, Joseph H; Kleim, Jörg-Peter; Stammers, David K.

Ren J; Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom.

J Med Chem ; 50(10): 2301-9, 2007 May 17.

Article en En | MEDLINE | ID: mdl-17441703

Asunto(s)

Fármacos Anti-VIH/química; Farmacorresistencia Viral; Transcriptasa Inversa del VIH/química; Transcriptasa Inversa del VIH/genética; VIH-1/genética; Modelos Moleculares; Quinoxalinas/química; Inhibidores de la Transcriptasa Inversa/química; Sitios de Unión; Cristalografía por Rayos X; Estructura Molecular; Mutación; Unión Proteica

Search on Google

Imprimir

XML

PubMed Links

Banco de datos: MEDLINE Asunto principal: Quinoxalinas / Modelos Moleculares / VIH-1 / Inhibidores de la Transcriptasa Inversa / Fármacos Anti-VIH / Farmacorresistencia Viral / Transcriptasa Inversa del VIH Idioma: En Año: 2007 Tipo del documento: Article

Search on Google

Imprimir

XML

PubMed Links