Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.
J Med Chem
; 50(10): 2450-8, 2007 May 17.
Article
en En
| MEDLINE
| ID: mdl-17444626
ABSTRACT
A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the alpha-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. The results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity.
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Banco de datos:
MEDLINE
Asunto principal:
Antiinflamatorios no Esteroideos
/
Ácido Tióctico
/
Quinolonas
/
Amidas
/
Antioxidantes
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article