C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.

Chao, Jianhua; Taveras, Arthur G; Chao, Jianping; Aki, Cynthia; Dwyer, Michael; Yu, Younong; Purakkattle, Biju; Rindgen, Diane; Jakway, James; Hipkin, William; Fosetta, James; Fan, Xuedong; Lundell, Daniel; Fine, Jay; Minnicozzi, Michael; Phillips, Jonathan; Merritt, J Robert

Chao, Jianhua; Taveras, Arthur G; Chao, Jianping; Aki, Cynthia; Dwyer, Michael; Yu, Younong; Purakkattle, Biju; Rindgen, Diane; Jakway, James; Hipkin, William; Fosetta, James; Fan, Xuedong; Lundell, Daniel; Fine, Jay; Minnicozzi, Michael; Phillips, Jonathan; Merritt, J Robert.

Chao J; Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. jianhua.chao@spcorp.com <jianhua.chao@spcorp.com>

Bioorg Med Chem Lett ; 17(13): 3778-83, 2007 Jul 01.

Article en En | MEDLINE | ID: mdl-17459706

Asunto(s)

Química Farmacéutica/métodos; Furanos/química; Furanos/farmacocinética; Receptores de Interleucina-8A/antagonistas & inhibidores; Receptores de Interleucina-8B/antagonistas & inhibidores; Administración Oral; Animales; Área Bajo la Curva; Perros; Diseño de Fármacos; Furanos/síntesis química; Humanos; Concentración 50 Inhibidora; Interleucina-8/química; Cinética; Ratones; Ratas

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Banco de datos: MEDLINE Asunto principal: Química Farmacéutica / Receptores de Interleucina-8A / Receptores de Interleucina-8B / Furanos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2007 Tipo del documento: Article

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