Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats.
Am J Respir Crit Care Med
; 176(3): 291-9, 2007 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-17478622
ABSTRACT
RATIONALE Inhaled nitric oxide (NO) has been used to prevent bronchopulmonary dysplasia, but with variable results. Ethyl nitrite (ENO) forms S-nitrosothiols more readily than does NO, and resists higher-order nitrogen oxide formation. Because S-nitrosylation is a key pathway mediating many NO biological effects, treatment with inhaled ENO may better protect postnatal lung development from oxidative stress than NO. OBJECTIVES:
To compare inhaled NO and ENO on hyperoxia-impaired postnatal lung development.METHODS:
We treated newborn rats beginning at birth to air or 95% O(2) +/- 0.2-20.0 ppm ENO for 8 days, or to 10 ppm NO for 8 days. Pups treated with the optimum ENO dose, 10 ppm, and pups treated with 10 ppm NO were recovered in room air for 6 more days. MEASUREMENTS AND MAINRESULTS:
ENO and NO partly prevented 95% O(2)-induced airway neutrophil influx in lavage, but ENO had a greater effect than did NO in prevention of lung myeloperoxidase accumulation, and in expression of cytokine-induced neutrophil chemoattractant-1. Treatment with 10 ppm ENO, but not NO, for 8 days followed by recovery in air for 6 days prevented 95% O(2)-induced impairments of body weight, lung compliance, and alveolar development.CONCLUSIONS:
Inhaled ENO conferred protection superior to inhaled NO against hyperoxia-induced inflammation. ENO prevented hyperoxia impairments of lung compliance and postnatal alveolar development in newborn rats.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alveolos Pulmonares
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Broncodilatadores
/
Nitritos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
/
Newborn
Idioma:
En
Año:
2007
Tipo del documento:
Article