Cerebellar cortical degeneration with selective granule cell loss in Bavarian mountain dogs.
J Small Anim Pract
; 48(8): 462-5, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17663663
ABSTRACT
Three Bavarian mountain dogs aged between 18 and 20 months, not related to each other, were presented with chronic signs of cerebellar dysfunction. On sagittal T2-weighted magnetic resonance imaging brain images, the tentative diagnosis of cerebellar hypoplasia was established based on an enlarged cerebrospinal fluid space around the cerebellum and an increased cerebrospinal fluid signal between the folia. Post-mortem examination was performed in one dog and did show an overall reduction of cerebellar size. On histopathologic examination, a selective loss of cerebellar granule cells with sparing of Purkinje cells was evident. Therefore, the Bavarian mountain dog is a breed where cerebellar cortical degeneration caused by the rather exceptional selective granule cell loss can be seen as cause of chronic, slowly progressive cerebellar dysfunction starting at an age of several months.
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Banco de datos:
MEDLINE
Asunto principal:
Degeneraciones Espinocerebelosas
/
Corteza Cerebelosa
/
Enfermedades de los Perros
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article