Aluminum impairs morphogenic transition and stimulates H(+) transport mediated by the plasma membrane ATPase of Yarrowia lipolytica.
FEMS Microbiol Lett
; 274(1): 17-23, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17663703
ABSTRACT
The effect of aluminum on dimorphic fungi Yarrowia lipolytica was investigated. High aluminum (0.5-1.0 mM AlK(SO(4))(2)) inhibits yeast-hypha transition. Both vanadate-sensitive H(+) transport and ATPase activities were increased in total membranes isolated from aluminum-treated cells, indicating that a plasma membrane H(+) pump was stimulated by aluminum. Furthermore, Al-treated cells showed a stronger H(+) efflux in solid medium. The present results suggest that alterations in the plasma membrane H(+) transport might underline a pH signaling required for yeast/hyphal development. The data point to the cell surface pH as a determinant of morphogenesis of Y. lipolytica and the plasma membrane H(+)-ATPase as a key factor of this process.
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Banco de datos:
MEDLINE
Asunto principal:
Transporte Iónico
/
ATPasas de Translocación de Protón
/
Yarrowia
/
Aluminio
/
Morfogénesis
Idioma:
En
Año:
2007
Tipo del documento:
Article